2025 AF Symposium Challenging Cases: Predicting the Origin of Non-PV Triggers

Dr. Francis Marchlinski
Dr. Francis Marchlinski of the University of Pennsylvania, Philadelphia, PA, was introduced as the leading researcher in non-PV triggers to improve the outcome of A-Fib ablation.
He began by talking about the case of a 74-year-old woman who developed Paroxysmal A-Fib in 2015. She was treated with the beta blocker Sotalol, then switched to the antiarrhythmic drugs Propafenone and Flecainide because of recurrence of her A-Fib.
Later, she developed infrequent but persistent A-Fib which required cardioversions.

Mapping non-PV triggers
Paroxysmal A-Fib—One Non-PV Trigger
This lead to her first ablation. Her Pulmonary Veins (PVs) were isolated and they found one non-PV trigger…







