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Case Studies: Testosterone Cures A-Fib in Aging Men

Much media attention has been paid to the importance of testosterone in men and how testosterone levels tend to decrease with aging. But few studies have looked at how low testosterone affects A-Fib and A-Fib stroke risk.



Low Testosterone Can Cause or Trigger Stroke

Low Testosterone can be responsible for or trigger acute ischemic stroke, stroke severity, and related death in men, according to Dr. George Eby of the George Eby Research Institute. Low testosterone is also associated with coronary disease, myocardial infarction (heart attack) in men, and with all-cause mortality in men.

Case Studies: Testosterone Cures A-Fib in Aging Men

In an article in the journal, Cardiology, Dr. Eby described cases where Testosterone Therapy (TT) made aging men A-Fib free.

Case #1: A 59-year-old man with a low Testosterone level of 361 ng/dl had daily A-Fib episodes for the last year. Other than PACs, he had no other heart problems.
Within 45 days of daily Testosterone Therapy (TT), his serum Testosterone rose to 1,489 ng/dl, and he had no instances of A-Fib and very few PACs. (After the second week of TT, his INR increased from 2.5 to 5.4 which required his Warfarin dosage to be lowered.)
 Case #2:A 59-year-old man had strongly symptomatic nocturnal paroxysmal A-Fib and depression. His serum Testosterone was only 150 mg/dl which is much lower than normal. Previously he had had congestive heart failure and persistent A-Fib which had been treated with ablation and cardioversion.
 He received both DHEA (25 mg/day) and natural testosterone (50 mg/day) as a gel applied to his shoulders. After Testosterone Therapy, his depression and ectopics ended with only two observed instances of A-Fib after two weeks.

Dr. Eby’s Conclusions

• “Testosterone Therapy (TT) is necessary, safe, and superior to antiarrhythmic drugs, and may prevent A-Fib and stroke in aging men.” According to Dr. Eby, “TT is a necessary, superior and safe natural rhythm treatment for A-Fib.” “TT may play an important role in treating A-Fib and preventing stroke in aging men.”

• “Testosterone is low in men with Lone A-Fib.” Testosterone has been shown to be low in men with lone A-Fib compared to non-A-Fib controls.

• “Beta-blockers lower testosterone [levels] in men.” Dr Eby also pointed out that beta-blockers lower testosterone in men.

• “Low Testosterone is a risk factor for stroke and death in men.” Testosterone is an independent risk factor for acute ischemic stroke, stroke severity, and related death in men. Low Testosterone is also associated with coronary disease and with myocardial infarction (heart attack) in men, and with all-cause mortality in men.

What This Means to Male A-Fib Patients

These may be the first reported cases of Testosterone Therapy for A-Fib and to prevent stroke in men. Obviously more research then a few case studies needs to be done on this subject.

If you are an aging man with A-Fib, you should have your Testosterone level checked. And for those with low Testosterone, raising your level, besides making you feel better and more youthful, may also prevent A-Fib and stroke.

References for this article

Eby, George. Cardiol 2007;1 17:c86-87. Doi:10.1016/j.mehy.2010.03.023

Lai j. et al. Reduced testosterone levels in males with lone atrial fibrillation. Clin Cardiol 2009;32:43-6. doi: 10.1002/clc.20423

Ravaglia, G. et al. Dehydroepiandrosterone-sulfate serum levels and common age-related diseases: results from a cross sectional Italian study of a general elderly population. Exp Gerontol 2002;37:701-12 doi:10.1016/S0531-5565(01)00232-7

Jeppensen LL et al;. Decreased serum testosterone in men with acute ischemic stroke. Thromb Vase Biol 1996;16:749-54.

Phillips, GB et al. The association of hypotestasteronemia with coronary disease in men. Arterioscler Thromb 1994;14:701-6.

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