Doctors & patients are saying about 'A-Fib.com'...
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Dr. Douglas L. Packer, MD, FHRS, Mayo Clinic, Rochester, MN
"Jill and I put you and your work in our prayers every night. What you do to help people through this [A-Fib] process is really incredible."
Jill and Steve Douglas, East Troy, WI
“I really appreciate all the information on your website as it allows me to be a better informed patient and to know what questions to ask my EP.
Faye Spencer, Boise, ID, April 2017
“I think your site has helped a lot of patients.”Dr. Hugh G. Calkins, MD Johns Hopkins,
Baltimore, MD
FAQs A-Fib Drug Therapy: Alternatives to Anticoagulants
“Is there an alternative to taking an anticoagulant? I have A-Fib, and my heart doctor wants me to take the anticoagulant Xarelto. I am concerned about the side effects. ”
All anticoagulants, i.e., Direct Oral Anticoagulants (DOACs) are inherently dangerous. You bruise easily, cuts take a long time to stop bleeding, you can’t participate in any contact sports or sports like bicycle racing with crash risk.
There is an increased risk of developing a hemorrhagic stroke and gastrointestinal bleeding. “Oral anticoagulants are high-risk medications” (Most EPs are well aware of the risks of life-long anticoagulation.)
Anticoagulants Protect You and Give Peace of Mind
But in spite of the possible negative effects of anticoagulants, if you have A-Fib and a real risk of stroke, anticoagulants do work. You’re no longer 4–5 times more likely to have an A-Fib (ischemic) stroke. Taking an anticoagulant to prevent an A-Fib stroke also may give you peace of mind.
What Else Can You Do? Remove the Reason for an Anticoagulant—Three Options
Be advised that no anticoagulant or blood thinner will absolutely guarantee you will never have a stroke. The best way to deal with the increased risk of stroke and side effects of anticoagulants is to no longer need them. Here are three options:
#1 Alternative: Get rid of your A-Fib.
As EP and prolific blogger Dr. John Mandrola wrote: “…if there is no A-Fib, there is no benefit from anticoagulation.”
Action: Request a catheter ablation procedure. Today, you can have an ablation immediately (called ‘first-line therapy’). You don’t have to waste a year on failed drug therapies. See Catheter Ablation Reduces Stroke Risk Even for Higher Risk Patients.
#2 Alternative: Close off your Left Atrial Appendage (LAA).
The Left Atrial Appendage is where 90%-95% of A-Fib clots originate.
Action: Request a Watchman device. The Watchman device is inserted to close off your LAA and keep clots from entering your blood stream. See Watchman Better Than Lifetime on Warfarin.
#3 Alternative: Consider non-prescription blood thinners
Ask your doctor about your CHA2DS2-VASc score (a stroke risk assessor). If your score is a 1 or 2 (out of 10), ask if you could take a non-prescription approach to a blood thinner.
Perhaps you can benefit from an increase in natural blood thinners such as turmeric, ginger and vitamin E or, especially, the supplement Nattokinase. See FAQ: “Are natural blood thinners as good as prescription blood thinners?”
Bottom Line
Whether or not to take anticoagulants (and which one) is one of the most difficult decisions you and your doctor must make. Talk to your doctor about alternatives to anticoagulants:
• Catheter ablation
• LAA closure (Watchman device)
• Non-prescription blood thinners
If you decide to take an anticoagulants, ask your doctor about taking Eliquis instead of Xarelto. Eliquis tested better than the other DOACs and is considered safer. To learn more see: (Finally) A Head-to-Head Comparison of Anticoagulants for A-Fib: Eliquis vs Xarelto.
Return to FAQ Drug Therapies
Last updated: Monday, September 28, 2026
